Table 2.
Clinical characteristics by groupa
| Characteristic | n=160
|
p-value | |
|---|---|---|---|
| COPDb (n=73) | No COPDc (n=87) | ||
| Smoking history, n (%) | <0.0001 | ||
| Never or <100 cigarettes | 2 (3) | 51 (59) | |
| Former | 48 (66) | 28 (32) | |
| Current | 23 (32) | 8 (9) | |
| Spirometry | |||
| FEV1, median | 2.0 | 2.6 | <0.0001 |
| Mean (SD) | 2.1 (0.6) | 2.6 (0.7) | |
| FEV1% predicted | 70.0 | 93.0 | <0.0001 |
| Mean (SD) | 74.0 (12.4) | 89.7 (14.6) | |
| FEV1/FVC, mean (SD) | 0.6 (0.1) | 0.8 (0.1) | <0.0001 |
| Peak flow (PEF) | 316.1 (102.86) | 403.5 (109.00) | <0.0001 |
| mMRC dyspnea scale (0–4 scale) | |||
| Median | 2 | 1 | <0.0001 |
| Mode (n, %) | 1 (34; 46) | 0 (71; 82) | |
| mMRC >2 | 20 (28) | 5 (6) | |
| CAT™ (0–40 scale) | |||
| Median | 15.0 | 4.0 | <0.0001 |
| Mean (SD) | 15.6 (8.0) | 5.5 (5.4) | |
| CAT >10, n (%) | 57 (78) | 13 (15) | <0.0001 |
| mMRC >2 or CAT >10, n (%) | 57 (78) | 15 (17) | <0.0001 |
| mMRC >2 and CAT >10, n (%) | 20 (28) | 3 (3) | <0.0001 |
| Comorbid conditions (any), n (%) yes | 73 (100) | 76 (87) | 0.0010 |
| Self-report activity on most days, n (%) | 0.0524 | ||
| Sit, lie down, walk around home | 38 (52) | 32 (37) | |
| Very active or exercise | 35 (48) | 55 (63) | |
Notes:
a
English-speaking subjects with informed consent and spirometry.
b
COPD, FEV1 60%–80% predicted, and no history of exacerbations >12 months.
c
No known diagnosis or treatment for COPD and FEV1/FVC ≥0.70.
Abbreviations: CAT, COPD Assessment Test; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; mMRC, modified Medical Research Council dyspnea scale; PEF, peak expiratory flow.