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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: FEBS J. 2017 Jun 22;285(1):28–41. doi: 10.1111/febs.14125

Figure 2. Metabolic rewiring in lung tumours from KrasG12D/+; p53-/- mice.

Figure 2

Schematic representation of metabolic networks in lung tumours from KrasG12D/+;p53-/- mice based on in vivo flux/tracing analyses. Enhanced flux from different labelled substrates is shown as indicated, with orange depicting glucose metabolism (based on 13C-Glucose [21, 57]); green: amino acid metabolism (13C-Leucine/Valine; solid), 15N-Leucine; dashed [25]); and purple: fatty acid metabolism (2H2O [62]). Grey arrow depicts similar flux relative to normal tissue [57]. Slc2a1, Glucose transporter 1; Acc, Acetyl-Co A carboxylase; Gcs, glutamylcysteine synthetase; Pdh, pyruvate dehydrogenase; Pc, pyruvate carboxylase.