Table 1.
DCs | Non-infected | hLF | mLF | BCG | BCG + hLF | BCG + mLF |
---|---|---|---|---|---|---|
TNF-α | 20 ± 11 | 10 ± 3 | 11 ± 4 | 946 ± 202 | 965 ± 192 | 969 ± 275 |
IL-6 | 11 ± 4 | 10 ± 5 | 11 ± 4 | 1166 ± 162 | 1139 ± 132 | 1159 ± 172 |
IL-1β | 0.7 ± 0.7 | 0.6 ± 0.5 | 0.8 ± 0.8 | 208 ± 246 | 261 ± 297 | 315 ± 336 |
IL-12p40 | 14 ± 17 | 6 ± 9 | 7 ± 9 | 841 ± 349 | 844 ± 373 | 966 ± 484 |
IL-10 | 6 ± 6 | 7 ± 6 | 6 ± 5 | 196 ± 104 | 226 ± 110 | 211 ± 108 |
BCG infected BMDCs cultured with or without recombinant human or mouse LF examined for cytokines involved in regulating MTB infection. Values given are in pg/ml and reported as mean ± standard deviation. Significant changes relative to BCG alone are shaded in grey; significant at p<0.05 using an unpaired Student T-test. Non-infected BMDCs, or control LF incubated cells, did not produce levels above background.