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. Author manuscript; available in PMC: 2018 Jun 18.
Published in final edited form as: J Bone Miner Res. 2017 Nov 17;33(3):499–509. doi: 10.1002/jbmr.3327

Fig. 2.

Fig. 2

Intravital microscopy of WT and Hyp calvaria demonstrates increased 3D lacunar size and decreased density of canaliculi in Hyp mice. (A) THG microscopy performed on d30 WT and Hyp calvaria. Representative 3D renderings of the osteocyte lacunocanalicular network was created with Imaris software using the microscopic images. (B) Quantitation of lacunar density, volume, and 3D surface area. (C) Evaluation of density of canaliculi and density of branched canaliculi extending from lacunar surface. Data are representative of that obtained from 4 mice per genotype. *p < 0.05. THG = third harmonic generation.