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. 2018 May 1;293(24):9388–9398. doi: 10.1074/jbc.RA118.001723

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© 2018 Aboudehen et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 1. — Identification of lncRNAs that are dysregulated in mouse models of ADPKD. A, kidney-specific inactivation of Pkd1 (Ksp/Cre;Pkd1^f/f) at postnatal day 10 (P10) and Pkd2 (Pkhd1/Cre;Pkd2^f/f) at P20 produces kidney cysts compared with control (Pkhd1/Cre;Pkd2^+/+). Kidneys were stained with H&E. B and C, identification by pair-end RNA-Seq of annotated (B) and novel (C) lncRNAs that are dysregulated in both Pkd1 and Pkd2 mutant kidneys (p < 0.05, log cpm >−1). D, mapping of dysregulated lncRNAs to genomic regions relative to protein-coding genes.