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. 2018 May 3;293(24):9248–9264. doi: 10.1074/jbc.RA117.000834

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© 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 9. — Deletion of Fpn in mature osteoclasts exhibits different effects on mitochondrial and nonmitochondrial respirations compared with osteoclast precursor cells. Bone marrow monocytes isolated from long bones of control (con) and Fpn-deleted (Fpn^ΔCtsk) mice were cultured with M-CSF + RANKL for 4 days to generate mature multinucleated osteoclasts (OC). Different fractions of mitochondrial and nonmitochondrial respirations per osteoclast were measured by Seahorse. n = 36–43. *, p < 0.05; **, p < 0.01; ****, p < 0.0001 versus control.