Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 1;293(24):9370–9387. doi: 10.1074/jbc.RA118.003278

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Lei et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

Figure 9. — Polar residues in the GLP-1R TM1 are coordinated by Asp-198 (TM2) in the inactive model, orienting key side chains away from TM7 and facilitating tight packing of TM1/TM7. View facing the TM1/TM2 boundary is shown. Key TM1 side chains interacting with Asp-198 are depicted in X-stick representation and labeled. A, inactive GLP-1R model. B, exendin-P5 (ExP5)/GLP-1R structure. C, GLP-1/GLP-1R structure. D, NNC1702/GCGR structure. E, 11-mer agonist/GLP-1R structure. TM helices are labeled in roman numerals.