Table 5.

Sequence variations in published structures

PDB code	Description	Structure fragment	Mutations/differences from hGLP-1R	Missing residues in the structure
5VEW (Song et al. 14)	Crystal structure of human GLP-1R transmembrane domain in complex with negative allosteric modulator PF-06372222	Residues 128–431. Residues 258–260 at intracellular loop 2 were replaced with T4 lysozyme. Residues 205–214 from ECL1 were replaced by a GSG linker	S193C, I196F, Y205G, ΔThr-207, ΔAla-208, ΔAla-209, ΔGln-210, ΔGln-211, ΔHis-212, ΔGln-213, W214G, S225A, M233X, S271A, I317C, G318I, K346A, C347F, G361C	Glu-128, Ser-129, Lys-130, Arg-131, Gly-132, Glu-133, Arg-134, Ser-135, Met-204, Asp-215, Glu-373, His-374, Ala-375, Arg-376, Gly-377, Thr-378, Leu-379, Glu-423, His-424, Leu-425, His-426, Ile-427, Gln-428, Arg-429, Asp-430, Ser-431
5NX2 (Jazayeri et al. 15)	Crystal structure of human GLP-1 receptor bound to the 11-mer agonist peptide 5	Residues 24–432	T207E, Q211A, D215R, L232F, L260F, G295A, T298A, C329A, P358A, G361A, H363V, V405A	Arg-24, Pro-25, Gln-26, Gly-27, Ala-28, Glu-418, Arg-419, Trp-420, Arg-421, Leu-422, Glu-423, His-424, Leu-425, His-426, Ile-427, Gln-428, Arg-429, Asp-430, Ser-431, Ser-432
5VAI (Zhang et al. 16)	Cryo-EM structure of active rabbit GLP-1 receptor in complex with GLP-1 and Gs protein	Residues 24–422	T106A, H112P, Q140R	Arg-24, Pro-25, Gln-26, Gly-27, Ala-28, Ser-129, Arg-130, Arg-131, Gly-132, Glu-133, Ser-134, Leu-422
6B3J (Liang et al. 17)	Cryo-EM structure of active human GLP-1 receptor in complex with exendin-P5 and Gs protein	Residues 23–466	None	Ala–23–Thr–29, Ser–129–Ser–136, Asn–338–Thr–342, His–424–Gly–466