Figure 6.

Increased seizure susceptibility in PTEN_{K13R, D384V} mice. A and B, mice were subjected to intraperitoneal injection of a standard amount of PTZ (75 mg/kg body weight). Latency to start seizure was determined in A. PTEN_{K13R, D384V} mice showed hypersensitivity to PTZ. B, percentage of mice that survived after PTZ injection. Most PTEN_{K13R, D384V} mice died after PTZ injection. 10 control and 10 PTEN_{K13R, D384V} mice were analyzed. Statistical analysis was performed using Student's t test: **, p < 0.01.