Figure 5.

Structure of the MIL–T2R–TTL complex. A, chemical structure of MIL. B, overall view of the complex formed between αβ-tubulin and MIL. C, close-up views of the interaction network observed between MIL (green sticks) and tubulin (black cartoon). Interacting residues of tubulin are shown in stick representation. Oxygen atoms are colored red and blue. D, superimposition of the MIL–T2R–TTL (cyan cartoon) and apo-T2R–TTL (black cartoon) structures. MIL is in green stick representation. Black arrows highlight regions of steric clashes between tubulin and MIL, purple arrow shows the large main chain changes between apo- from MIL complex.