Table 2.
Verification of activities of taxol, vinblastine, SKLB028, SKLB050 on A2780S, A2780/T, HCT-8, HCT-8/V, and HCT-8/T cells
MTT assay was used to detect the IC50 (half-maximal inhibitory concentration) values. The data are expressed as means ± S.D.
| IC50 | |||||
|---|---|---|---|---|---|
| n m | |||||
| Cell lines | A2780S | A2780/T | HCT-8 | HCT-8/V | HCT-8/T |
| Paclitaxel | 46 ± 5 | 8600 ± 1000 (186)a | 36 ± 6 | 9200 ± 430 (255) | 10,800 ± 670 (300) |
| Vinblastine | 33 ± 7 | 7540 ± 876 (225) | 27 ± 3 | 9800 ± 670 (362) | 19,800 ± 1200 (733) |
| SKLB028 | 72 ± 8 | 150 ± 19 (2.1) | 98 ± 11 | 134 ± 13 (1.4) | 201 ± 56 (2.1) |
| SKLB050 | 23 ± 4 | 35 ± 5 (1.5) | 13 ± 2 | 19 ± 1 (1.5) | 33 ± 5 (2.5) |
a The numbers in parentheses are the calculated relative resistance values, obtained by dividing the IC50 value of the resistant line by the IC50 value of the parental line.