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. 2018 Jun 18;13(6):e0199211. doi: 10.1371/journal.pone.0199211

Fig 6. Schematic proposition of the TLR canonical signaling pathway through TIRAP by PTEN regulation.

Fig 6

PTEN alterations may lead to upregulation of TLR signaling pathway and may increase tumor cell proliferation. Loss of PTEN repressor role by its deletion or phosphorylation, as may occur more frequently in classical subtype, may activate downstream TLR canonical pathway through the decreased inhibition over TIRAP. This pathway through TIRAP-PTEN may not be the major mechanism in mesenchymal subtype, and the integrity of PTEN may inhibit TIRAP and then not activate this pathway in proneural subtype.