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. 2018 Jun 18;13(6):e0199281. doi: 10.1371/journal.pone.0199281

Table 3. SEM analyses of associations between the flanker task and waist circumference through the metabolic risk factors (β-values and 95% CI).

Reaction Time Accuracy Interference score
Congruent Incongruent Congruent Incongruent Reaction time Accuracy
Waist circumference–cognition:
including MET cluster score as mediator
Direct associations
Waist circumference (c’)
1.26 (-3.63–6.14) 1.07 (-5.57–7.70) -0.26 (-0.84–0.33) -1.09 (-2.28–0.10) -0.19 (-3.88–3.49) 0.83 (-0.10–1.76)
Indirect associations
Waist circumference → MET cluster score → (a1 b1)
1.39 (-0.31–3.08) 1.95 (0.35–4.26)* -0.09 (-0.29–0.11) 0.06 (-0.34–0.47) 0.57 (-0.69–1.83) -0.15 (-0.47–0.16)
Waist circumference–cognition:
including HDLc as mediator
Direct associations
Waist circumference (c’)
1.82 (-2.84–6.47) 1.89 (-4.44–8.21) -0.37 (-0.93–0.18) -1.15 (-2.28 –-0.02)* 0.07 (-3.45–3.59) -0.77 (-0.11–1.66)
Indirect associations
Waist circumference → HDLc → (a1 b1)
0.82 (-0.06–1.72) 1.13 (-0.08–2.34)* 0.03 (-0.07–0.12) 0.12 (-0.08–0.32) 0.30 (-0.31–0.92) -0.09 (-0.25–0.06)
Waist circumference–cognition:
including HOMA score as mediator
Direct associations
Waist circumference (c’)
2.09 (-2.64–6.82) 2.43 (-3.99–8.86) -0.27 (-0.84–0.02) -0.94 (-2.09–0.21) 0.34 (3.22–3.91) 0.67 (-0.23–1.56)
Indirect associations
Waist circumference → HOMA score → (a1 b1)
0.56 (-0.55–1.66) 0.59 (-0.91–2.08) -0.07 (-0.21–0.06) -0.09 (-0.35–0.18) 0.03 (-0.79–0.85) 0.01 (-0.19–0.22)
Waist circumference–cognition:
including Sys BP as mediator
Direct associations
Waist circumference (c’)
2.76 (-2.03–7.54) 3.44 (-3.06–9.95) -0.25 (-0.82–0.32) -1.01 (-2.17–0.15) 0.69 (-2.92–4.29) 0.76 (-0.14–1.67)
Indirect associations
Waist circumference → Sys BP → (a1 b1)
-0.11 (-1.42–1.20) -0.42 (-2.21–1.36) -0.10 (-0.26–0.06) 0.01 (-0.33–0.30) -0.31 (-1.30–0.68) -0.08 (-0.33–0.16)
Waist circumference–cognition:
including TG as mediator
Direct associations Waist circumference (c’) 2.15 (-2.50–6.81) 1.97 (-4.34–8.27) -0.32 (-0.87–0.24) -1.01 (-2.14–0.12) -0.19 (-3.68–3.31) 0.69 (-0193–1.57)
Indirect associations Waist circumference → TG → (a1b1) 0.49 (-0.26–1.24) 1.05 (-0.06–2.16) -0.03 (-0.11–0.06) 0.02 (-0.19–0.15) 0.56 (-0.05–1.17) -0.01 (-0.14–0.12)

Structural equation models (SEM).

* p<0.05. β-values are partially standardized and should be interpreted as the changes in absolute values of the cognitive outcomes for each standard deviation change in the exposure (metabolic risk factors).