Flow diagram of study patients enrolled in the RESTORE (Randomized Evaluation of Sedation Titration for Respiratory Failure) trial, including follow-up. *Follow-up rate: 1,073/1,360 = 79%. †Parents/guardians provided health-related quality of life data via Infant and Toddler Quality of Life Questionnaire (ITQOL) or Pediatric Quality of Life Inventory (PedsQL). For ITQOL, parents/guardians provided data for 53 patients 6 years of age or older; these data were analyzed separately, as the instrument is validated for children younger than 6 years of age. For PedsQL, parents/guardians provided incomplete data for five patients, so that the PedsQL could not be scored. SP = sedation protocol; UC = usual care.