Figure 1.

Increased SELPLG (selectin P ligand) expression levels in ventilator-induced lung injury (VILI) and LPS models of preclinical murine lung injury. Affymetrix Mouse Genome 430 2.0 Arrays were used to profile whole-genome gene expression levels in both (A) VILI and (B) LPS models, including SELPLG. The robust multiarray average function in the “affy” package of Bioconductor was used to summarize the expression level of each probe set. SELPLG expression is markedly increased in both preclinical murine models of acute respiratory distress syndrome. Box-and-whisker plots show median (line inside the box), first and third quartiles (bottom and top of box), and 1.5 × interquartile range (whiskers). *P < 0.05 compared with control. WT = wild type.