Figure 4.

LPS-induced lung injury is attenuated in Selplg^−/− mice. Wild-type (WT) C57/B6 mice or Selplg^−/− mice were challenged with LPS (1 mg/kg, intratracheal instillation, 18 h). LPS produces robust increases in (A) total BAL protein levels and (B) total leukocyte counts in WT C57/B6 mice. Both LPS-induced increases in BAL protein levels and total leukocyte counts were significantly attenuated in Selplg^−/− mice. Results are expressed as mean (±SEM); n = 3 per condition; *P < 0.05. Selplg = selectin P ligand; Veh = vehicle.