Table 2.

Characteristics of the Acute Respiratory Distress Syndrome–associated SNPs and Associated Gene Sets

GWAS-associated Results								ICSNPathway-associated Results
−log10(Nominal GWAS P Value Threshold)	Chromosome (Coordinate)	Assayed SNP in GWAS	Reference/Alternative Alleles	GWAS Nominal P Value of Assayed SNP	Minor Allele Frequency (1000 Genomes)		Functional Class/eQTL SNPs (Yes/No)	Associated Gene	Candidate Causal Pathway	FDR-corrected P Value of Candidate Causal Pathway Prioritized with ICSNPathway Method Given Various Distances Flanking the Gene of Interest
					African American	European				Within	5 KB	20 KB	100 KB
4	1 (236,739,416)	rs2115740	T/C	6.53 × 10−5	0.4836	0.2992	Intronic (yes)	HEATR1	GO:0042254: ribosome biogenesis and assembly	0.021	0.007	0.074	0.028
3	12 (109,017,898)	rs2228315	T/C	2.74 × 10−4	0.2951	0.06759	Nonsynonymous coding, altering methionine to isoleucine (yes)	SELPLG	GO:0050901: leukocyte tethering or rolling	0.01	0.01	0.004	0.006
									BIOCARTA pathway: granulocytes pathway	0.069	0.182	0.013	0.024
	10 (71,176,066)	rs61732394	T/C	6.24 × 10−4	0.08197	<0.0001	Nonsynonymous coding, altering aspartic acid to glycine (no)	TACR2	GO:0008528: peptide receptor activity, G protein coupled	0.025	0.102	0.062	0.002
									GO:0042277: peptide binding	0.029	0.205	0.02	0.002
									GO:0042923: neurotransmitter binding	0.824	0.217	0.004	0.005
									GO:0042923: neuropeptide binding	0.183	0.205	0.011	0.002
									GO:0008188: neuropeptide receptor activity	0.073	0.048	0.011	0.022

Definition of abbreviations: eQTL = expression quantitative trait loci; FDR = false discovery rate; GWAS = genome-wide association study; ICSNPathway = Identify Candidate Causal SNPs and Pathways.