Table 3.
Three Missense Mutations in Exon 3 on the SELPLG Gene
| SNP | Position | Allele | Residue Change | Discovery Population: AA (n = 394) |
MESSI Cohort |
Meta-analysis |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA (n = 362) |
EA (n = 607) |
|||||||||||||
| MAF | OR (95% CI) | P Value | MAF | OR (95% CI) | P Value | MAF | OR (95% CI) | P Value | OR (95% CI) | P Value | ||||
| rs7300972 | 109017264 | C/T | Met→Val | 0.24 | 0.76 (0.55–1.05) | 0.11 | 0.27 | 1.28 (0.91–1.79) | 0.43 | 0.01 | 0.21 (0.05–0.96) | 0.05 | 0.95 (0.75–1.20) | 0.65 |
| rs61729674 | 109017266 | A/G | Ser→Phe | 0.18 | 0.66 (0.46–0.96) | 0.03 | 0.19 | 1.12 (0.80–1.78) | 0.15 | 0.01 | 0.10 (0.01–0.74) | 0.02 | 0.86 (0.67–1.11) | 0.24 |
| rs2228315 | 109017898 | T/G | Met→Ile | 0.31 | 2.06 (1.42–2.99) | 1.5 × 10−4 | 0.27 | 0.97 (0.69–1.37) | 0.36 | 0.07 | 1.41 (0.89–2.24 | 0.14 | 1.38 (1.10–1.72) | 0.005 |
Definition of abbreviations: AA = African ancestry; CI = confidence interval; EA = European ancestry; Ile = isoleucine; MAF = minor allele frequency; MESSI = Molecular Epidemiology of Sepsis in the Intensive Care Unit; Met = methionine; OR = odds ratio; Phe = phenylalanine; SELPLG = selectin P ligand gene; Ser = serine; Val = valine.
Results of the discovery population are based on imputed data (allelic association was examined with logic regression adjusting for age, sex, sepsis, and three principal components using PLINK). For the MESSI cohort, the logistic regression was used assuming an additive genetic model and adjusting for one (European) or two (African) principal components.