Table 2.
Final PopPK model: pharmacokinetic parameter estimates and bootstrap results
| Base model | Final model | Bootstrap (1000 runs) | ||||||
|---|---|---|---|---|---|---|---|---|
| Estimate | RSE (%) | Shrinkage (%) | Estimate | RSE (%) | Shrinkage (%) | Median value | 95% CI | |
| PK parameter | ||||||||
| CL 70 kg (l h −1 ) | 13.58 | 1.97 | 13.70 | 2.43 | 13.69 | 13.12–14.16 | ||
| V 70 kg (l) | 50.05 | 1.21 | 49.57 | 1.15 | 49.57 | 49.72–50.76 | ||
| GSTA1 ‐group on CL (Reference G2) | ||||||||
| G3 | 0.88 | 0.40 | 0.89 | 0.82–0.96 | ||||
| G1 | 1.07 | 4.40 | 1.07 | 1.05–1.21 | ||||
| PMA on V | −0.06 | 23.40 | −0.06 | −0.18–0.09 | ||||
| Between‐subject variability (BSV) | ||||||||
| BSV CL (%) | 18.30 | 9.00 | 6.20 | 13.30 | 8.80 | 6.00 | 18.80 | 15.00–21.20 |
| BSV V (%) | 11.50 | 15.40 | 22.30 | 7.00 | 19.20 | 24.60 | 7.48 | 3.64–9.95 |
| Between‐occasion variability (BOV) | ||||||||
| BOV CL (%) | 7.40 | 8.00 | 46.10 | 7.30 | 8.10 | 46.60 | 7.44 | 6.12–8.28 |
| BOV V (%) | 10.00 | 18.60 | 21.50 | 9.60 | 16.40 | 9.30 | 9.57 | 4.94–12.40 |
| Random residual variability | ||||||||
| σ [Proportional error (%)] | 7.40 | 7.90 | 7.40 | 7.90 | 27.20 | 25.00–29.00 | ||