Table 3.
Clinical and laboratory characteristics of the 12 fatal cases of influenza
| Season | Isolated virus | Age/sex | BMI | Body temperature at presentation (°C) | Pre‐existing condition | Cause of death | Microbiologic test | Antiviral drug treatment (days from symptom onset to administration of antiviral) | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Sputum culture | Blood culture | Pneumococcal urinary antigen test | ||||||||
| 2011‐2012 | A/Ansan/D16/2012 (H3N2) | 78/M | 27.5 | None | Diabetes, hypertension, chronic cerebrovascular disease | Pneumonia | Streptococcus pneumoniae | Not done | Positive | Oseltamivir 75 mg bid (0) plus |
| Peramivir 300 mg qd (1) | ||||||||||
| A/Suwon/C276/2012 (H3N2) | 89/M | 24.2 | 37.3 | Diabetes, hypertension, chronic respiratory diseases, BPH | Exacerbation of COPD | MRSA | Not done | Negative | Oseltamivir 75 mg bid (1) | |
| 2012‐2013 | A/Seoul/A468/2013 (H3N2) | 89/M | 23.7 | 37.6 | None | Multi‐organ failure | Streptococcus pneumoniae | Not done | Positive | Peramivir 100 mg qd (5) |
| A/Cheongju/G792/2013 (H1N1) | 74/F | 15.2 | 38 | Cancer | Pneumonia | Normal flora | Not done | Positive | Oseltamivir 150 mg bid (1) plus | |
| Peramivir 300 mg qd (3) | ||||||||||
| A/Ansan/D342/2013 (H3N2) | 72/M | 20.7 | 38.6 | Chronic cardiovascular disease, AML | Pneumonia | Pseudomonas aeruginosa | Pseudomonas aeruginosa | Negative | Oseltamivir 75 mg bid (2) plus | |
| Peramivir 250 mg qd (2) | ||||||||||
| A/Cheongju/G856/2013 (H3N2) | 93/F | 20 | Non | Chronic cerebrovascular disease | Pneumonia | No growth | Not done | Negative | Oseltamivir 75 mg bid (1) | |
| 2013‐2014 | A/Ansan/D765/2014 (H3N2) | 80/M | 23.1 | 38.6 | Chronic respiratory diseases, COPD | Pneumonia, sepsis | Normal flora | Not done | Not done | Oseltamivir 75 mg bid (1) |
| A/Cheongju/G1532/2014 (H3N2) | 86/F | 17.8 | 36.8 | Hypertension | Pneumonia, sepsis | Normal flora | Staphylococcus aureus | Negative | Oseltamivir 75 mg bid (1) | |
| A/Cheongju/G1629/2014 (H3N2) | 86/M | 16.5 | 37.5 | COPD | Pneumonia | MRSA | Not done | Negative | Oseltamivir 75 mg bid (7) | |
| 2014‐2015 | A/Seoul/A1284/2015 (H3N2) | 97/F | 20.2 | 37.8 | Diabetes, chronic respiratory diseases, anemia, dementia, osteoporosis | Pneumonia | Pseudomonas fluorescens | Not done | Negative | Peramivir 300 mg qd (1) |
| A/Seoul/A1251/2015 (H3N2) | 92/M | 17.9 | 38.2 | Diabetes, asthma, chronic respiratory diseases, TB, BPH | Pneumonia, sepsis | MRSA, Escherichia coli | Not done | Negative | Peramivir 300 mg qd (2) | |
| A/Cheongju/G2156/2015 (H3N2) | 83/F | 17.3 | None | Hypertension, chronic respiratory diseases | Pneumonia | Not done | Not done | Negative | Oseltamivir 75 mg bid (3) | |
BMI, body mass index; BPH, benign prostatic hyperplasia; COPD, chronic obstructive pulmonary disease; TB, tuberculosis; AML, acute myeloid leukemia; MRSA, methicillin‐resistant Staphylococcus aureus.