UBM treatment reduces pain. UBM-treated mice have reduced pain at 4 weeks compared to PBS control mice. a UBM-treated mice have reduced time on the hotplate compared to PBS control mice, indicating less pain in the operated leg. b UBM-treated mice have increased weight placed on the operated leg as measured by incapacitance testing, also indicating less pain on the operated leg. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001