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. Author manuscript; available in PMC: 2019 Jun 12.
Published in final edited form as: Curr Opin Chem Biol. 2018 Jun 12;44:39–46. doi: 10.1016/j.cbpa.2018.05.012

Figure 1. The regulatory network of cholesterol catabolism and utilization is a vulnerable drug target.

Figure 1

Cholesterol metabolites induce the expression of genes in the KstR1, KstR2, and Mce3R regulons. Enzymes encoded in the KstR1 and KstR2 regulons catabolize cholesterol and are regulated by PTMs, cAMP, and mycothiol potential. The Mce3R regulon influences stress resistance and is targeted by 6-azasteroids. cAMP regulates protein acyltransferases and cAMP production is increased by small molecule V-58.