Table 1.

Post-translationally modified proteins utilized for cholesterol metabolism.

Rv Number	Protein	Pathway	Modification1	Function
Rv0066c	Icd2	TCA Cycle		Isocitrate dehydrogenase
Rv0467	Icl	Glyoxylate Cycle & Methylcitrate Cycle		Isocitrate lyase (2-methylcitrate lyase)
Rv0889c	CitA	TCA Cycle		Citrate synthase
Rv0951	SucC	Succinyl-CoA Transformation		Succinyl-CoA synthetase β-subunit
Rv0952	SucD	Succinyl-CoA Transformation		Succinyl-CoA synthetase α-subunit
Rv1143	Mcr	Cholesterol Side Chain Degradation		α-methyl-acyl-CoA racemase
Rv1240	Mdh	TCA Cycle & Glyoxylate Cycle		Malate dehydrogenase
Rv1492	MutA	Methylmalonyl-CoA Pathway		Methylmalonyl-CoA mutase (small subunit)
Rv1493	MutB	Methylmalonyl-CoA Pathway		Methylmalonyl-CoA mutase (large subunit)
Rv1837c	GlcB	Glyoxylate Cycle		Malate synthase G
Rv2215	DlaT	Pyruvate Transformation		Pyruvate dehydrogenase E2 component
Rv2241	AceE	Pyruvate Transformation		Pyruvate dehydrogenase E1 component
Rv3280	AccD5	Methylmalonyl-CoA Pathway		Propionyl-CoA carboxylase
Rv3281	AccE5	Methylmalonyl-CoA Pathway		Propionyl-CoA carboxylase
Rv3285	AccA3	Methylmalonyl-CoA Pathway		Propionyl-CoA carboxylase
Rv3339c	Icd1	TCA Cycle		Isocitrate dehydrogenase
RV3504	ChsE4	Cholesterol Side Chain Degradation		Acyl-CoA dehydrogenase (α-subunit)
Rv3516	EchA19	Cholesterol Side Chain Degradation		Enoyl-CoA hydratase
Rv3542c	ChsH2	Cholesterol Side Chain Degradation		MaoC-like enoyl-CoA hydratase (β-subunit)
Rv3546	FadA5	Cholesterol Side Chain Degradation	S–S	3-Keto-acyl-CoA thiolase
Rv3556c	FadA6	Cholesterol CD Ring Degradation		3-Keto-acyl-CoA thiolase
Rv3561	FadD3	Cholesterol CD Ring Degradation		Fatty acid-CoA ligase
Rv3563	FadE32	Cholesterol CD Ring Degradation		Acyl-CoA dehydrogenase (β-subunit)
Rv3568c	HsaC	Cholesterol AB Ring Degradation		3,4-DHSA dioxygenase
Rv3569c	HsaD	Cholesterol AB Ring Degradation		4,9-DHSA hydrolase
RV3570c	HsaA	Cholesterol AB Ring Degradation		3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase

¹Red circle: acetylation; yellow star: succinylation; S–S: disulfide formation.