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. Author manuscript; available in PMC: 2018 Jun 18.
Published in final edited form as: Nature. 2017 Jun 28;546(7660):676–680. doi: 10.1038/nature22977

Figure 1. Vegfr3Luc reporter mice for whole-body analysis of benign and malignant melanocytic lesions.

Figure 1

a, Vegfr3Luc mouse models in this study. b, Xenografts of mCherry-SK-Mel-147 imaged as indicated. c, Confocal immunomicroscopy of Vegfr3 (red) and Lyve1 (green) in normal skin or in xenografts by SK-Mel-147. d, Four main patterns (I–IV) of V3-Luc emission identified by whole-body bioluminescence of xenografts of the indicated melanoma cell lines. Numbers represent days upon implantation and dotted lines tumor area. e, V3-Luc at the indicated locations and tumor sizes. Average tumor volumes are indicated in the X-axis, and visualized with a dotted red line for simplicity. Data are mean ± SD (6 mice per condition, 24 LN per cell line). One-way Anova/Dunnett's correction for multiple comparisons. Fluorescence: p/s/cm2/sr ×109; bioluminescence: p/s/cm2/sr ×106. See Source Data for V3-Luc quantifications in panel (e).