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. Author manuscript; available in PMC: 2018 Jun 18.
Published in final edited form as: Adv Exp Med Biol. 2018;1074:289–295. doi: 10.1007/978-3-319-75402-4_35

Table 35.1.

Changes in the amounts of metabolism proteins in AIPL−/− retinas. P10 retinas from AIPL1−/− and littermates were analyzed by proteomics. Significant changes in levels of proteins related to metabolism are listed. Green highlights downregulated and red highlights upregulated proteins compared to control. N = 7. Spectral count was shown as mean ± SD

Gene Protein WT AIPL1 Metabolic pathway
AIPL1 Aryl-hydrocarbon-interacting protein-like 1 11±1.5 0 cGMP degradation
PDE6b Phosphodiesterase 6B 40±1.6 0 cGMP degradation
PDE6a Phosphodiesterase 6A 53±1.6 3±1.4 cGMP degradation
Cmtr1 S-adenosyl-L-methionine-dependent methyltransferase 7±2.5 3±0.4 RNA methyl transferase
Sar1b GTP-binding protein SAR1b 4±1.5 1±0.4 Nucleotide binding
Ehd4 EH domain-containing protein 4 3±1.0 1±0.4 Nucleotide binding
Gng11 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 3±1 1±0.4 Nucleotide binding
Pepd Xaa-Pro dipeptidase 2±0 4±1.5 Collagen metabolism
Rab3ip Rab-3A-interacting protein 2±0.5 4±1.5 Nucleotide exchange
Mbnl2 Isoform 2 of muscleblind-like protein 2 1±0.4 5±1.5 RNA metabolism
Slc39a7 Zinc transporter SLC39A7 0 3±1.0 Metal transport
Mccc2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondria 0 3±0.6 Leucine degradation