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. Author manuscript; available in PMC: 2018 Jun 18.
Published in final edited form as: Adv In Insect Phys. 2014;46:389–433. doi: 10.1016/B978-0-12-417010-0.00005-7

Figure 5.10.

Figure 5.10

Effect of alanine substitution at F1579 (F4il5A) or Y1586 (Y4i22A) in Nav1.4 channels on sensitivity to inhibition by SCBIs. Nav1.4 channels were expressed in Xenopus oocytes equilibrated with indoxacarb, DCJW, or RH-3421 for 15 min at a holding potential of −30 mV. A 2-s hyperpolarizing pulse to −120 mV was used to relieve channel inactivation, but not block by SCBIs, prior to the test pulse.