Table 1.
Clinicopathological features according to the expression of clock genes in The Cancer Genome Atlas metastatic melanomas.
|
P-values* |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variables | BMAL1 | CRY1 | CRY2 | CLOCK | NR1D1 | PER1 | PER2 | PER3 | RORA |
| Age | 0.59 | 0.592 | 0.998 | 0.151 | 0.057 | 0.19 | 0.754 | 0.002 | 0.286 |
| Gender | 0.659 | 0.271 | 0.269 | 0.269 | 0.015 | 0.06 | 0.028 | <0.001 | 0.269 |
| Pathologic stage | 0.817 | 0.643 | 0.644 | 0.083 | 0.247 | 0.418 | 0.132 | 0.037 | 0.417 |
| Ulceration status | 1 | 0.404 | 0.094 | 0.889 | 1 | 0.78 | 0.267 | 0.889 | 1 |
| Mitotic count | 0.769 | 0.175 | 0.07 | 0.801 | 0.465 | 0.256 | 0.276 | 0.613 | 0.963 |
| Breslow thickness | 0.731 | 0.545 | 0.65 | 0.847 | 0.179 | 0.816 | 0.823 | 0.961 | 0.838 |
P-values in bold are statistically significant.
*Two-sided Wilcoxon–Mann–Whitney (continuous variables) or Chi-square exact test (categorical variable) comparing tumors with high vs. low expression.