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. 2018 Jun 12;9:628. doi: 10.3389/fphar.2018.00628

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Copyright © 2018 Bai, Li, Zhao, Li, Li, Feng, Qin, Tian and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nrf2 siRNA prevented the anti-fibrosis effect of Jinshui Huanxian formula (JHF) on TGF-β1-induced MRC-5 cells. (A) MRC-5 cells were transfected with Cy3-labeled siRNA (red), scale bars: 300 μm. (B) The effect of JHF on the mRNA level of Nrf2 in TGF-β1-treated fibroblasts transfected with Nrf2 siRNA. (C) The effect of JHF on the mRNA levels of α-SMA, FN1 in TGF-β1-treated fibroblasts transfected with Nrf2 siRNA. Values represented as mean ± SEM. ^aaP < 0.01, versus NC control group. ^bbP < 0.01, ^bP < 0.05, versus NC model group. ^ccP < 0.01, versus Nrf2 siRNA control group.