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Three-dimensional structures of the COX-1 and COX-2 homodimers. (A) Highlight of the catalytic site domains and the heme grouping in both chains making up the proteins COX-1 (PDB ID: 4O1Z) and COX-2 (PDB ID: 5KIR). (B) The two conformational states (CS1 and CS2) assumed by quercetin in the molecular docking calculations for COX-1.
