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. 2018 Jun 12;9:617. doi: 10.3389/fphar.2018.00617

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Copyright © 2018 Lescano, Freitas de Lima, Mendes-Silvério, Justo, da Silva Baldivia, Vieira, Sanjinez-Argandoña, Cardoso, Mónica and Pires de Oliveira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interactions of quercetin at the catalytic site of COX-1. In (A) the polar residues are highlighted, mainly Tyr₃₈₅ and in (B) the non-polar residues. Quercetin: orange (CS1) and gray (CS2) previously displayed in Figure 6.