Table 1.

Binding affinities of functionally distinct RNases for RNA and DNA ligands.

	Kd 3′-UMP (μM)	Kd 5′-AMP (μM)	Kd dATATA (μM)a
RNA_Bovine	9.7 ± 0.9b	124 ± 1b	N/Ac
RN2_Human	455.9 ± 10.6	539.6 ± 31.4	383.9 ± 33.3
RN3_Human	460 ± 100	300 ± 45	302 ± 31
RN4_Human	10, 320±622	1, 324±72	72.9 ± 9
RN5_Human	1, 942±105	2, 476±77	N/Ac

^aSingle-stranded penta-deoxyribonucleotide (DNA) substrate analog of adenine and thymine nucleotide bases.

^bTaken from Gagné et al. (2012).

^cNot available.