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. 2018 Jun;9(3):487–494. doi: 10.21037/jgo.2018.02.02

Table 2. Univariate and multivariate analysis for overall survival.

Variable Median OS (mo) UV MV
HR (95% CI) P value HR (95% CI) P value
Age (years) 0.26 0.72
   <70 21.6 ref. ref.
   ≥70 15.6 1.56 (0.72, 3.37) 0.81 (0.25, 2.63)
Sex 0.93 0.22
   Male 17.7 ref. ref.
   Female 15.6 1.04 (0.46, 2.32) 0.54 (0.20,1.44)
Pathologic AJCC tumor stage 0.64 0.13
   T1/2 20.5 ref. ref.
   T3/4 15.6 1.21 (0.55, 2.65) 2.56 (0.76, 8.63)
Pathologic AJCC nodal status 0.35 0.09
   N0 15.4 ref. ref.
   N1 32.1 0.68 (0.31, 1.51) 0.25 (0.05, 1.25)
Nodes removed 0.06 0.08
   <5 12.2 ref. ref.
   ≥5 32.1 0.46 (0.21, 1.02) 0.31 (0.09, 1.15)
Tumor grade
   Well/moderate 17.7 ref. ref.
   Poor/undifferentiated 12.9 0.65 (0.22, 1.95) 0.44 0.59 (0.16, 2.20) 0.43
   Unknown 20.9 1.20 (0.35, 4.09) 0.77 0.99 (0.25, 3.89) 0.98
Surgical margins 0.74 0.39
   Negative 19.6 ref. ref.
   Positive 12.7 1.18 (0.44, 3.19) 0.52 (0.12, 2.33)
Post-op CA 19-9
   <90 32.1 ref. ref.
   ≥90 12.3 5.37 (1.74, 16.5) 0.003 5.55 (1.20, 25.7) 0.03
   Unknown 11.1 2.11 (0.88, 5.06) 0.09 1.32 (0.42, 4.17) 0.64
Adjuvant radiation 0.036 0.006
   No 11.3 ref. ref.
   Yes 21.6 0.43 (0.20, 0.95) 0.15 (0.04, 0.58)

Statistically significant P values are in italic. mo, month; UV, univariate; MV, multivariate; HR, hazard ratio; ref., reference.