Table 4. The frequency of grade 1–2 and grade 3–4 toxicities in patients with DPYD*9A, DPYD*2A and DPYD*9B variants.

Adverse events	DPYD Mutant (N=17), N [%]
	DPYD*9A (N=13#)			DPYD*2A (N=3)			DPYD*9B (N=2#)
	Grade 1–2	Grade 3–4		Grade 1–2	Grade 3–4		Grade 1–2	Grade 3–4
Hematological
Neutropenia	6 [46]	0 [0]		2 [67]	1 [33]		1 [50]	0 [0]
Anemia	6 [46]	0 [0]		1 [33]	0 [0]		1 [50]	0 [0]
Thrombocytopenia	1 [8]	0 [0]		1 [33]	0 [0]		1 [50]	0 [0]
Neutropenic fever	0 [0]	0 [0]		0 [0]	0 [0]		0 [0]	0 [0]
Non-hematological
Mucositis	2 [15]	1 [8]		1 [33]	0 [0]		0 [0]	0 [0]
Nausea	7 [54]	1 [8]		1 [33]	0 [0]		2 [100]	0 [0]
Vomiting	5 [38]	1 [8]		0 [0]	0 [0]		2 [100]	0 [0]
Diarrhea	1 [8]	8 [62]		0 [0]	3 [100]		0 [0]	2 [100]
Neurotoxicity	0 [0]	0 [0]		0 [0]	0 [0]		0 [0]	0 [0]
Skin toxicity	1 [8]	3 [23]		1 [33]	0 [0]		0 [0]	1 [50]

^#, one patient had double heterozygous status for DPYD*9A and DPYD*9B variants.