Table 3. FDA based classification of drugs used for MDR-TB treatment during pregnancy.

MDR-TB drug	FDA classification
Pyrazinamide	C
Fluoroquinolones: levofloxacin; moxifloxacin; ofloxacin	C
Aminoglycosides: kanamycin; amikacin; streptomycin	D
Capreomycin	C
Ethionamide/prothionamide	C
Cycloserine/terizidone	C
Para-aminosalicylic acid	C
High-dose isoniazid	C
Clofazimine	C
Linezolid	C
Amoxicillin/clavulanate	B
Clarithromycin	C
Imipenem/cilastatin	C
Meropenem	B
Bedaquiline	B
Delamanid	Not FDA approved

FDA pregnancy categories: A—human studies demonstrate no risk; B—animal studies demonstrate no risk, no human studies; C—animal studies demonstrate risk, no human studies; D—human studies demonstrate risk; X—contraindicated in pregnancy.