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. 2018 Jun 18;8:9259. doi: 10.1038/s41598-018-27050-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Model illustrating the localisation changes of IFT (B) members under knockdown of different IFT genes in Paramecium. (A) Normal IFT process in WT cells. (B) When IFT process was disrupted by the depletion of IFTA proteins such as IFT139, IFTB proteins (IFT46, IFT57) were accumulated at the cilia tip. (C) Depletion of several IFTB proteins, including IFT57 and IFT172, prevented other IFTB proteins (IFT46, IFT57) from entering the cilia. (D) Absence of IFT46 in Paramecium cells provoked the accumulation of other IFTB member (IFT57) in the cortex and cytoplasm.