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. 2018 Jun 18;9:2382. doi: 10.1038/s41467-018-04591-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — RV-specific antibody responses in sera from children with acute wheeze. Frequencies and levels of a IgG and b IgA responses (y-axes: n, number of reactive sera) to the N-terminal VP1 peptides from 30 RV strains (Supplementary Tables 2 and 4) (x-axes: red: RV-A species; green: RV-B species; blue: RV-C species). Antibody levels are color-coded and expressed as ISAC standardized units, ISU-G and ISU-A, respectively. c Median IgG levels (y-axis: ISU-G) to VP1 peptides (x-axis) in children grouped according to age (6–12 months: squares; 13–24 months: triangles; 25–42: circles). d Spearman’s rank correlation between the number of IgG-reactive peptides (n, y-axis; median IgG >15 ISU) and age (x-axis: months). Correlation coefficient (ρ) and p-value are shown. e Comparison of the number of IgG-reactive VP1 peptides (n, y-axis; median IgG >15 ISU) in children according to age (x-axis). Horizontal lines indicate medians. Statistically significant differences between groups are indicated (**p < 0.01, ****p < 0.0001) (Mann–Whitney U-test)