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p21 is a potential downstream mediator of p53 function in hormone-exposed mammary glands. Because p21 is a direct target of p53 action and is a cell cycle inhibitor, p21 expression was examined in the mammary glands of hormone-treated and AMV glands 3 days post-MNU by IHC. (A and B) AMV, 3 days post-MNU; (C and D) E/P-treated, 3 days post-MNU.
