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p21 expression in AMV and EP-treated BALB/c mammary glands 6 days post-DMBA. DNA damage activates p53, which in turn would mediate cell cycle arrest by up-regulation of p21 and other genes. We therefore examined p21 expression by IHC in hormone-treated and AMV BALB/c mice 6 days after DMBA challenge. (A and B) AMV, 6 days DMBA; (C and D) E/P-treated, 6 days DMBA.
