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. 2001 Oct 16;98(22):12379–12384. doi: 10.1073/pnas.221459098

Figure 7.

Figure 7

Proliferation block in hormone-treated BALB/c mice 6 and 10 days after DMBA challenge. BALB/c mice were treated with the hormonal regimen described. On day 97 the control and hormone-treated mice were given 1 mg of DMBA by oral gavage. The mammary glands were collected 0, 3, 6, and 10 days post-DMBA administration. BrdUrd (30 mg/kg of body weight) was administered to the animals 2 h before killing. Cell proliferation in the virgin and hormone-treated glands before and after DMBA treatment was analyzed by BrdUrd IHC. The percentage of BrdUrd-labeled cells was plotted against days after DMBA treatment. Each value represents mean ± SEM. Differences between groups were tested for statistical significance by using the paired Student's t tests. Different superscripts indicate that the values are statistically different within a group.