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. 2018 Jun 7;43(7):1424–1438. doi: 10.1007/s11064-018-2558-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 7 — BpV(pic) induces the functional recovery in ischemic stroke animals through PTEN inhibition and ERK 1/2 activation. a Animals treated with bpV(pic) have lower scores in mNSS test at day 7 and 14 after ischemia–reperfusion injury compared with I/R + Vehicle group. Animals injected with IV and/or U0126 before injected with bpV(pic) show a higher scores in mNSS test at day 7 and 14 after ischemia–reperfusion than I/R + bpV(pic) group [n = 6 for each group, *P < 0.05 vs. the I/R + Vehicle,^#P < 0.05 vs. the I/R + bpV(pic)]. b Animals treated with bpV(pic) have lower scores in beam-walking test at day 3, 7 and 14 after ischemia–reperfusion injury compared with I/R + Vehicle group. Animals injected with IV and/or U0126 before injected bpV(pic) show a higher scores in beam-walking test at day 3, 7 and 14 after ischemia–reperfusion than I/R + bpV(pic) group [n = 6 for each group, *P < 0.05 vs. the I/R + Vehicle,^#P < 0.05 vs. the I/R + bpV(pic)]. c Animals treated with bpV(pic) have a highter ratio in MST test at day 14 after ischemia–reperfusion injury compared with I/R + Vehicle group. Animals injected with IV and/or U0126 before injected bpV(pic) show lower ratio in MST test at day 14 after ischemia–reperfusion than I/R + bpV(pic) group [n = 6 for each group, *P < 0.05 vs. the I/R + Vehicle,^#P < 0.05 vs. the I/R + bpV(pic)]. The datas are expressed as mean ± SE. Statistical analysis was implemented by student’s t-test and variance analysis