Table 2.

Associations between preoperative hemodynamic parameters and postoperative AKI severity early after heart transplantation

	Univariable model		Multivariable modelf
	OR (95% CI)	p value	OR (95% CI)	p value
Total cohorta
PAPic	0.88 (0.79–0.99)	0.043*	0.85 (0.75–0.96)	0.008*
RAPc	1.12 (0.99–1.28)	0.07	1.16 (1.02–1.32)	0.029*
RAP-to-PCWPc	1.19 (1.01–1.39)	0.033*	1.15 (0.98–1.35)	0.10
Heart rated	0.90 (0.81–1.00)	0.06	0.98 (0.87–1.11)	0.75
SVRe	0.96 (0.91–1.00)	0.06	0.96 (0.92–1.01)	0.13
Subgroup RAP ≥ 6 mmHgb
PAPic	0.74 (0.60–0.92)	0.006*	0.70 (0.56–0.87)	0.002*
RAPc	1.62 (1.17–2.25)	0.004*	1.78 (1.27–2.50)	0.001*
RAP-to-PCWPc	1.44 (1.06–1.96)	0.019*	1.31 (0.95–1.08)	0.10
Heart rated	0.88 (0.77–1.01)	0.08	0.95 (0.82–1.11)	0.52
SVRe	0.98 (0.92–1.03)	0.42	0.99 (0.93–1.05)	0.78

OR (95% CI) indicates proportional odds ratio with 95% confidence interval; for other abbreviations, please see Table 1

*p value < 0.05 is statistically significant

^aTotal n = 595, no AKI = 165, AKI stage 1 = 278, AKI stage 2 = 66, AKI stage 3 = 86

^bTotal n = 340, no AKI = 94, AKI stage 1 = 147, AKI stage 2 = 42, AKI stage 3 = 57

^cOR are given per doubling of a preoperative hemodynamic parameter. OR are interpreted as the odds of having a more severe renal injury for any level of AKI (stage 3, stage 2, stage 1, and no AKI). For example, if RAP increases from 7 to 14 mmHg (i.e., doubled), the odds of having AKI stage 3 versus combined AKI stages ≤ 2 and no AKI are 1.12 times greater. Likewise, the odds of having AKI stages ≥ 2 versus combined AKI stage 1 and no AKI are 1.12 times greater. Finally, the odds of having AKI of any stage versus no AKI are 1.12 times greater

^dOR are given per 10-unit increase in preoperative heart rate (interpretation is the same as under c)

^eOR are given per 100 dyne/sec/cm² Increase in preoperative SVR (interpretation is the same as under c)

^fPreoperative hemodynamic parameters were adjusted for all variables with p < 0.10 in univariable analysis and included patient’s BMI, baseline eGFR, diabetes, donor’s age and sex, ischemia time of donor’s heart, time from catheterization to HTx, postoperative RVF, and the postoperative use of induction therapy. Associations between these variables and postoperative AKI stages are presented in Table S1