Table 2.
Genotype Distributions and Allele Frequencies of TNFR2 Polymorphisms Between Cases and Controls.
| Model | Controls | CHB | LC | HCC | CHB vs Controls | LC vs Controls | HCC vs Controls | |||
|---|---|---|---|---|---|---|---|---|---|---|
| n = 269 (%) | n = 115 (%) | n = 86 (%) | n = 272 (%) | R(95%CI)* | P* | R(95%CI)* | P* | R(95%CI)* | P* | |
| rs1061622 | ||||||||||
| T | 460 (85.5) | 203 (88.3) | 151 (87.8) | 469 (86.2) | Reference | Reference | Reference | |||
| G | 78 (14.5) | 27(11.7) | 21 (12.2) | 75 (13.8) | 0.775 (0.453–1.325) | 0.352 | 0.893 (0.522–1.529) | 0.680 | 0.964 (0.661–1.407) | 0.850 |
| TT | 196 (72.9) | 90 (78.3) | 66 (76.7) | 200 (73.5) | Reference | Reference | Reference | |||
| TG | 68 (25.3) | 23 (20.0) | 19 (22.1) | 69 (25.4) | 0.721 (0.388–1.307) | 0.273 | 0.884 (0.480–1.628) | 0.692 | 0.970 (0.631–1.492) | 0.890 |
| GG | 5 (1.9) | 2 (1.7) | 1 (1.2) | 3 (1.1) | 1.001 (0.118–8.519) | 0.999 | 0.851 (0.090–7.368) | 0.855 | 0.870 (0.176–4.289) | 0.864 |
| Dominant model | ||||||||||
| TT | 196 (72.9) | 90 (78.3) | 66 (76.7) | 200 (73.5) | Reference | Reference | Reference | |||
| TG + GG | 73 (27.2) | 25 (21.7) | 20 (23.3) | 72 (26.5) | 0.725 (0.400–1.314) | 0.289 | 0.880 (0.483–1.601) | 0.675 | 0.965 (0.632–1.471) | 0.867 |
| Recessive model | ||||||||||
| TT + TG | 264 (98.1) | 113 (98.3) | 85 (98.8) | 269 (98.9) | Reference | Reference | Reference | |||
| GG | 5 (1.9) | 2 (1.7) | 1 (1.2) | 3 (1.1) | 1.104 (0.131–9306) | 0.928 | 0.845 (0.094–7.593) | 0.880 | 0.877 (0.178–4.307) | 0.871 |
| rs1061624 | ||||||||||
| G | 324 (60.2) | 120 (52.6) | 87 (51.2) | 304 (55.7) | Reference | Reference | Reference | |||
| A | 214 (39.8) | 108 (47.4) | 83 (48.8) | 242 (44.3) | 1.363 (0.949–1.959) | 0.094 | 1.432 (0.995–2.060) | 0.053 | 1.272 (0.973–1.662) | 0.078 |
| GG | 76 (28.3) | 27 (23.7) | 14 (16.5) | 60 (22.0) | Reference | Reference | Reference | |||
| GA | 172 (63.9) | 66 (57.9) | 59 (69.4) | 184 (67.4) | 1.128 (0.625–2.038) | 0.689 | 1.895 (0.972–3.693) | 0.06 | 1.563 (1.009–2.422) | 0.046# |
| AA | 21 (7.8) | 21 (18.4) | 12 (14.1) | 29 (10.6) | 2.666 (1.126–6.316) | 0.026# | 2.947 (1.130–7.689) | 0.027# | 1.955 (0.939–4.073) | 0.073 |
| Dominant model | ||||||||||
| GG | 76 (28.3) | 27 (23.7) | 14 (16.5) | 60 (22.0) | Reference | Reference | Reference | |||
| GA + AA | 193 (71.7) | 87 (76.3) | 72 (83.5) | 212 (78) | 1.314 (0.742–2.329) | 0.349 | 2.016 (1.046–3.887) | 0.036# | 1.605 (1.043–2.470) | 0.031# |
| Recessive model | ||||||||||
| GG + GA | 248 (92.8) | 94 (81.6) | 74 (85.9) | 243 (89.4) | Reference | Reference | Reference | |||
| AA | 21 (7.8) | 21 (18.4) | 12 (14.1) | 29 (10.6) | 2.459 (1.145–5.281) | 0.021# | 1.830 (0.817–4.099) | 0.142 | 1.411 (0.703–2.728) | 0.305 |
*Adjusted for age, gender, ethnicity, smoking, alcohol consumption,and BMI.
#The data reach statistical significance.