Table 1.

Pathway analysis showing the top 5 significantly up- or downregulated pathways of aCDCs versus yCDCs (P < 0.05; z-score ≥ |1.5|).

Pathway	z-score	Genes
Cell cycle: G2/M DNA damage checkpoint regulation	−2,324	TOP2A,BRCA1,AURKA,CDKN2A,CCNB2,CDC25C,BORA,PKMYT1,CKS2,GADD45A,CKS1B,PRKCZ,PLK1,CDK1,CCNB1,CHEK1,CDC25B
Oestrogen-mediated S-phase entry	2,714	CCNE2,CCNA1,CCND1,E2F2,CDK2,CDC25A,E2F1,CCNA2,RBL1,ESR1,CDK1
Role of BRCA1 in DNA damage response	1,500	BRCA1,RFC3,FANCB,E2F1,BLM,TOPBP1,DPF1,FANCD2,RFC5,FANCE,STAT1,E2F2,SMARCD3,RFC2,FANCG,FANCA,RBL1,GADD45A,BRCA2,RAD51,PLK1,CHEK1
Mitotic roles of Polo-like kinase	1,807	KIF23,ESPL1,CDC25A,PRC1,CDC20,CCNB2,KIF11,CDC25C,CDC7,PKMYT1,PLK4,PLK2,PTTG1,HSP90AA1,PLK1,CDK1,CCNB1,FBXO5,CDC25B
ATM signalling	1,500	BRCA1,MAPK10,CDK2,CDC25A,GADD45B,CCNB2,SMC2,H2AFX,CDC25C,BLM,FANCD2,CREB5,MAPK13,GADD45A,RAD51,CDK1,CCNB1,CHEK1

ATM, ataxia telangiectasia mutated; BRCA1, breast cancer 1.