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. 2018 Jun 18;8:9307. doi: 10.1038/s41598-018-27638-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of isocryptotanshinone on proliferation of SGC-7901 and MKN-45 cells. (A) shows the chemical structure of ICTS. SGC-7901 (B) and MKN-45 (D) cells were treated with the indicated concentration of ICTS for 48 hours, and the proliferation was assessed using the Cell Counting Kit (CCK)−8 assay. SGC-7901 (C) and MKN-45 (E) cells were treated with 10 or 20 μM ICTS for the indicated time respectively, and the cell growth was determined using the CCK-8 assay. Data were expressed as mean ± standard error of triplicates from a representative experiment. *P < 0.05 and **P < 0.01 versus the control group (DMSO or 0 h group). ICTS, isocryptotanshinone.