Table I.
Research advances of MALAT1 in cancers.
| Cancers | Function of MALAT1 | (Refs.) |
|---|---|---|
| NSCLC | Associated with metastasis and survival | (4) |
| A prognostic parameter for stage I and stage II NSCLC | (4,16) | |
| Contributes to brain metastasis | (24) | |
| Esophageal Squamous cell carcinoma | Promotes tumor proliferation and metastasis | (25) |
| Gastric cancer | Promotes the development and peritoneal metastasis of cancer | (26) |
| Promotes cell proliferation | (35) | |
| CRC | A negative prognostic factor to patients with stage II/III CRC | (27) |
| Hepatocellular carcinoma | Predicts a significantly increased risk of tumor recurrence following liver transplantation | (28) |
| Modulating cell proliferation | (59) | |
| Pancreatic cancer | Unfavorable predictor for its clinical progression and prognosis | (29) |
| Promotes cell growth, migration and invasion | (30) | |
| Promotes the stem cell-like phenotypes in cancer cells | (70) | |
| Clear cell renal carcinoma | Associated with proliferation, migration and invasion, indicates tumor progression and poor prognosis | (31) |
| Bladder cancer | Promotes cell migration with the EMT | (32) |
| Mediates the TGFβ-induced EMT and promotes tumor metastasis | (75) | |
| Urothelial carcinoma of the bladder | Associated with proliferation, apoptosis and motility | (33) |
| Castration-resistant prostate cancer | Maintains tumorigenicity | (34) |
| Involved in RNA processing and resulting in incomplete splicing | (35) | |
| Breast cancer | Involved in the inhibitory effect of 17β-Estradiol treatment on breast tumor cell proliferation, migration and invasion | (36) |
| Regulated EMT | (68) | |
| Cervical cancer | Associated with the positive of human papilloma virus in cervical squamous cells | (37) |
| Effected cervical cancer cell proliferation and invasion | (38) | |
| Adrenocortical cancer | The second most upregulated lncRNA | (39) |
| Multiple myeloma | Predicts early progression | (40) |
| Melanoma | Associated with the metastasis | (41) |
| Osteosarcoma | Promotes tumor proliferation and metastasis | (42) |
| Involved in drug action in high-grade osteosarcoma | (51) | |
| Neuroblastoma | Involved in neuroblastoma cells migration and invasion | (48) |
| Glioblastoma | Affects the migration of glioblastoma cells | (81) |
MALAT1, metastasis-associated lung adenocarcinoma transcript 1; EMT, epithelial-mesenchymal transition; lncRNA, long non-coding RNA; TGFβ, transforming growth factor β; CRC, colorectal cancer; NSCLC, non-small cell lung cancer.