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. 2018 Jun 18;8:9251. doi: 10.1038/s41598-018-27527-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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mRNA sequencing reveals transcriptome changes in 2 m Tau hippocampus. (A) Heat map shows genes that are significantly altered by Tau OE in 2 m hippocampi (n = 6 ctrl; 5 Tau). (B) qPCR data summary for normalized Prnp, C4b, and Trem2 mRNA levels in 2 m hippocampi. (C) Inflammatory Response, Cell-To-Cell Signaling and Interaction, Cellular Function and Maintenance network is one of the top networks altered in 2 m Tau hippocampi.