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. 2018 Jun 18;8:9251. doi: 10.1038/s41598-018-27527-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MiR142-OE in cortical neurons in vivo results in substantial transcriptome changes in cortex of wildtype mice. (A) Schematics of in-utero electroporation (IUE) technique used to overexpress miR142. (B) Localization of miR142-GFP (green) in neurons (red) but not in astrocytes (red) after IUE. (C) qPCR summary for normalized levels of miR142 (-3p and -5p) in the cortex of 1 m wildtype mice. (D) Heat map shows genes that are significantly altered by miR142-OE in wildtype cortex at 1 m (ctrl, n = 5; miR142OE, n = 5).