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. 2018 Jun 18;8:9281. doi: 10.1038/s41598-018-27615-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression and function of LXRs in hepatic MNCs. (a) Hepatic MNCs were isolated from the liver of WT mice, and mRNA copy numbers of LXRα (Nr1h3) and LXRβ (Nr1h2) were compared to those in whole liver samples (n = 8 for each group). LXRα (Nr1h3) and LXRβ (Nr1h2) mRNA levels were also evaluated in isolated F4/80⁺CD11b⁺ and F4/80⁺CD11b⁻ cells (n = 4 for each group). n.d., not detected. *P < 0.05; **P < 0.01; ***P < 0.001; n.s., not significant (one-way ANOVA followed by Tukey’s multiple comparisons for 4 groups of WT samples). (b) Thioglycolate elucidated-peritoneal macrophages and hepatic MNCs isolated were isolated from WT and LXRα/β-KO mice and were treated with vehicle control (ethanol), T0901317 (1 μM), 24,25(S)-epoxycholesterol (24,25EC) (10 μM), or GW3965 (1 μM) for 18 hours. Abca1 mRNA levels were quantified (n = 3 for each group). *P < 0.05; ***P < 0.001 compared to Control (one-way ANOVA followed by Tukey’s multiple comparisons); ^#P < 0.05; ^##P < 0.01, ^###P < 0.001 compared to WT (Student’s t test). (c) WT mice were fed a diet containing vehicle control (corn oil), or T0901317 (10 or 20 mg/kg/day (mpk)) for 7 days. Abca1 mRNA levels in hepatic MNCs were examined (n = 4 for each group). *P < 0.05 compared to control (one-way ANOVA followed by Tukey’s multiple comparisons). mRNA values were normalized with Ppib (a) or Gapdh (b,c) mRNA levels.