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. 2018 Jun 18;8:9281. doi: 10.1038/s41598-018-27615-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Elevated expression of M1 macrophage markers in hepatic MNCs and F4/80⁺ Kupffer cells/macrophages of LXRα/β-KO mice. mRNA expression of macrophage surface markers (Adgre1, Itgam, Cd68), M1 and M2 macrophage markers (M1: Il12b, Il1b, Nos2; M2: Arg1, Retnla, Cd163) in hepatic MNCs (a), F4/80⁺CD11b⁺ cells (b), and F4/80⁺CD11b⁻ cells (c) were evaluated (MNCs, n = 8; F4/80⁺CD11b⁺ cells, n = 4; F4/80⁺CD11b⁻ cells, n = 4 for each genotype). mRNA expression of monocyte chemoattractant protein-1 (Ccl2) (d) in hepatic MNCs, whole liver and F4/80⁺CD11b⁺ cells from WT and LXRα/β-KO mice were also examined (MNCs, n = 8; whole liver, n = 8; F4/80⁺CD11b⁺ cells, n = 4 for each genotype). mRNA levels were quantified and normalized with Gapdh or Ppib mRNA levels. *P < 0.05; **P < 0.01; ***P < 0.001 compared to WT (Student’s t test).