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. 2018 Jun 18;9(7):720. doi: 10.1038/s41419-018-0760-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Co-localization of IGF-1 and NF-200 in DRG neurons. b Neurons treated with IGF-1 (25 ng/ml) for 48 h showed increased neurite outgrowth while IGF-1-neutralizing antibody reduced the effect. Scale bar: 20 μm. The longest neurite outgrowth from DRG neurons was observed and compared with control. The expression change of IGF-1 at mRNA (c) and protein levels (d) in DRG neurons transfected with miR-129 mimic (miR-129) and miR-129 inhibitor (anti-miR-129). β-actin was used as an internal control. e Transfection of miR-129 mimic or inhibitor in DRG neurons, respectively. f A prior lesion of the sciatic nerve promoted axon regeneration in intact DRG neurons, meanwhile the IGF-1 treatment enhanced the axon regrowth. The regrowth effect was abolished in miR-129 mimic transfected DRG neurons. Scale bar: 20 μm, *p < 0.05 and **p < 0.01 versus respective controls. NC (mimic control), anti-NC (inhibitor control)